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公开(公告)号：US10736883B2
公开(公告)日：2020-08-11
申请号：US16347903
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Matthew Brown , Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , James S. Harvey , Julie Anne Heath , Lars V. Heumann , Jonathan Houze , Frank Kayser , Aarif Yusuf Khakoo , David j. Kopecky , Su-Jen Lai , Zhihua Ma , Julio C. Medina , Jeffrey T. Mihalic , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Malgorzata Wanska , Wen-Chen Yeh
IPC: A61K31/4196 , A61K31/341 , C07D405/04 , C07D405/14 , A61K31/421 , A61K31/437 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D239/26 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07F7/08 , A61P9/00 , A61P9/02 , C07D307/54
Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.
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公开(公告)号：US09988369B2
公开(公告)日：2018-06-05
申请号：US15584109
申请日：2017-05-02
Applicant: AMGEN INC.
Inventor： Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Mikkel V. Debenedetto , Paul John Dransfield , Zice Fu , James S. Harvey , Julie Anne Heath , Simon J. Hedley , Jonathan Houze , Ted C. Judd , Aarif Yusuf Khakoo , David John Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Wen-Chen Yeh
IPC: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D405/04 , C07D471/04 , C07D498/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14
CPC classification number: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , C07D498/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20180222895A1
公开(公告)日：2018-08-09
申请号：US15945852
申请日：2018-04-05
Applicant: AMGEN INC.
Inventor： Xiaoqi Chen , Alan C. Cheng , Richard V. Connors , Mikkel V. Debenedetto , Paul John Dransfield , Zice Fu , James S. Harvey , Julie Anne Heath , Jonathan Houze , Ted C. Judd , David John Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang
IPC: C07D405/14 , C07D409/14 , C07D403/14 , C07D403/04 , C07D401/14 , A61K45/06 , A61K31/4439 , A61K31/437 , A61K31/506 , A61K31/5383 , C07D498/04 , C07D405/04 , C07D471/04 , A61K31/497
CPC classification number: C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , C07D498/04
Abstract: Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.
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公开(公告)号：US10906890B2
公开(公告)日：2021-02-02
申请号：US16347955
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Ning Chen , Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Julie Anne Heath , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Charles Kreiman
IPC: C07D403/14 , C07D239/24 , C07D241/12 , C07D249/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D239/26 , A61P9/04 , C07D401/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US11020395B2
公开(公告)日：2021-06-01
申请号：US16347942
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong Chen , Paul John Dransfield , James S. Harvey , Julie Anne Heath , Jonathan Houze , Aarif Yusuf Khakoo , David J. Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Philip Dean Ramsden
IPC: A61K31/506 , A61P9/04 , C07D403/12 , C07D405/14 , C07D401/14 , C07D413/04 , C07D403/14 , A61K31/4439 , C07D401/04 , A61K31/4196 , C07D249/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.
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Patent Agency Ranking
公开(公告)号：US10689367B2
公开(公告)日：2020-06-23
申请号：US16347970
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong Chen , Alan C. Cheng , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Vatee Pattaropong , Gayathri Swaminath , Charles Kreiman , David C. Moebius , Ankit Sharma
IPC: C07D401/14 , C07D405/14 , C07D413/14 , A61P9/04 , C07D417/14 , A61K45/06 , C07D401/12
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.
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公开(公告)号：US11191762B2
公开(公告)日：2021-12-07
申请号：US16347924
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Philip Dean Ramsden , Ankit Sharma
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/506 , A61P9/04 , A61K31/4439 , A61K31/4196 , C07D413/04 , C07D401/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US11149040B2
公开(公告)日：2021-10-19
申请号：US16760947
申请日：2018-10-25
Applicant: AMGEN INC.
Inventor： Paul John Dransfield , James S. Harvey , Zhihua Ma , Ankit Sharma
IPC: C07D487/04 , C07D498/04 , C07D498/14 , A61K31/395 , A61K31/553 , A61P9/00 , C07F7/08 , A61K45/06
Abstract: Compounds of Formula I, pharmaceutically acceptable salts thereof, tautomers thereof, pharmaceutically acceptable salts of the tautomers, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US11046680B1
公开(公告)日：2021-06-29
申请号：US16347910
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , James S. Harvey , Julie Anne Heath , Lars V. Heumann , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , Frank Kayser , Aarif Yusuf Khakoo , David J. Kopecky , Su-Jen Lai , Zhihua Ma , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Malgorzata Wanska , Kevin Yang , Wen-Chen Yeh
IPC: C07D417/14 , A61P9/00 , C07D401/14 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04
Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US10150760B2
公开(公告)日：2018-12-11
申请号：US15945852
申请日：2018-04-05
Applicant: AMGEN INC.
Inventor： Xiaoqi Chen , Alan C. Cheng , Richard V. Connors , Mikkel V. Debenedetto , Paul John Dransfield , Zice Fu , James S. Harvey , Julie Anne Heath , Jonathan Houze , Ted C. Judd , David John Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang
IPC: C07D405/14 , C07D403/14 , C07D409/14 , C07D401/14 , C07D403/04 , A61K45/06 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , C07D498/04 , C07D405/04 , C07D471/04 , A61K31/437
Abstract: Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.
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