Disclosed are a device and a method for calibrating a reference voltage. The reference voltage calibrating device includes a data signal communication unit that transmits/receives a data signal, a data strobe signal receiving unit that receives a first data strobe signal and a second data strobe signal, a voltage level of the second data strobe signal being opposite to a voltage level of the first data strobe signal, and a reference voltage generating unit that sets a reference voltage for determining a data value of the data signal, based on the first data strobe signal and the second data strobe signal, and the reference voltage generating unit adjusts the reference voltage based on the first data strobe signal and the second data strobe signal.