A system configured to perform cascade echo cancellation processing to improve a performance when reference signals are asymmetric (e.g., dominant reference signal(s) overshadow weak reference signal(s)). The system may perform cascade echo cancellation processing to separately adapt filter coefficients between the dominant reference signal(s) and the weak reference signal(s). For example, the system may use a dominant reference signal to process a microphone audio signal and generate a residual audio signal, using the residual audio signal to adapt first filter coefficient values corresponding to the dominant reference signal. Separately, the system may use a weak reference signal to process the residual audio signal and generate an output audio signal, using the output audio signal to adapt second filter coefficient values corresponding to the weak reference signal.