发明授权
![Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride](/docs/US/2022-02-08/US11242314B2/abs.jpg.600x600.jpg)
- 专利标题： Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride
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申请号： US15403954申请日： 2017-01-11
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公开(公告)号： US11242314B2公开(公告)日： 2022-02-08
- 发明人: Dong Zhou , Wenhua Chu
- 申请人： Dong Zhou , Wenhua Chu
- 申请人地址： US MO St. Louis; US MO St. Louis
- 专利权人： Dong Zhou,Wenhua Chu
- 当前专利权人： Dong Zhou,Wenhua Chu
- 当前专利权人地址： US MO St. Louis; US MO St. Louis
- 代理机构： Polsinelli PC
- 主分类号： C07C315/04
- IPC分类号： C07C315/04 ; C07D213/52 ; C07D213/71 ; C07H3/02 ; C07H19/06 ; C07D233/91 ; C07D207/09 ; C07C247/04 ; C07C67/307 ; C07C45/63 ; C07C303/22 ; C07J1/00 ; C07B59/00
![Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride](/abs-image/US/2022/02/08/US11242314B2/abs.jpg.150x150.jpg)
摘要：
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.
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