A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.