- 专利标题： Triaryl compounds for treatment of PD-L1 diseases
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申请号： US16874212申请日： 2020-05-14
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公开(公告)号： US11266643B2公开(公告)日： 2022-03-08
- 发明人: Pingchen Fan , Christopher Lange , Venkat Reddy Mali , Darren J. McMurtrie , Viengkham Malathong , Sreenivas Punna , Rajinder Singh , Ju Yang , Yibin Zeng , Penglie Zhang
- 申请人： CHEMOCENTRYX, INC.
- 申请人地址： US CA Mountain View
- 专利权人： CHEMOCENTRYX, INC.
- 当前专利权人： CHEMOCENTRYX, INC.
- 当前专利权人地址： US CA Mountain View
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo PC
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/4985 ; C07D471/04 ; C07D401/12 ; A61K31/506 ; C07D403/12
摘要：
Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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