公开(公告)号：US12054484B2

公开(公告)日：2024-08-06

申请号：US17357427

申请日：2021-06-24

申请人： CHEMOCENTRYX, INC.

发明人： Junfa Fan ,  Jaroslaw Kalisiak ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Jeffrey P. McMahon ,  Jay P. Powers ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： A61K31/35 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  A61K31/538 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D309/24 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/536 ,  A61K31/538 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  A61P37/00 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′):




and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.

公开(公告)号：US11684606B2

公开(公告)日：2023-06-27

申请号：US17527939

申请日：2021-11-16

申请人： CHEMOCENTRYX, INC.

发明人： James J. Campbell ,  Karen Ebsworth ,  Antoni Krasinski ,  Venkat Reddy Mali ,  Jeffrey McMahon ,  Rajinder Singh ,  Ju Yang ,  Chao Yu ,  Penglie Zhang

IPC分类号： A61K31/4035 ,  A61P29/00 ,  A61P17/06

CPC分类号： A61K31/4035 ,  A61P17/06 ,  A61P29/00

摘要： The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula:

公开(公告)号：US11266643B2

公开(公告)日：2022-03-08

申请号：US16874212

申请日：2020-05-14

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher Lange ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Viengkham Malathong ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D405/12 ,  A61K31/4985 ,  C07D471/04 ,  C07D401/12 ,  A61K31/506 ,  C07D403/12

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10683294B2

公开(公告)日：2020-06-16

申请号：US15991747

申请日：2018-05-29

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61P37/02

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US20160296508A1

公开(公告)日：2016-10-13

申请号：US15074965

申请日：2016-03-18

申请人： ChemoCentryx, Inc.

发明人： Daniel Dairaghi ,  Dean R. Dragoli ,  Jarek Kalisiak ,  Christopher W. Lange ,  Manmohan Reddy Leleti ,  Yandong Li ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Viengkham Malathong ,  Jay P. Powers ,  Hiroko Tanaka ,  Joanne Tan ,  Matthew J. Walters ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/47 ,  A61K31/4709

CPC分类号： A61K31/47 ,  A61K31/4709 ,  C07D215/48 ,  C07D405/04 ,  C07D405/14

摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:

公开(公告)号：US12011439B2

公开(公告)日：2024-06-18

申请号：US17820179

申请日：2022-08-16

申请人： CHEMOCENTRYX, INC.

发明人： Shijie Li ,  Venkat Reddy Mali ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/4545 ,  A61K31/165 ,  A61K31/357 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K31/4545 ,  A61K31/165 ,  A61K31/357 ,  A61K39/39541 ,  A61P35/00

摘要： The present disclosure is drawn to the combination therapy of a C-C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

公开(公告)号：US11708326B2

公开(公告)日：2023-07-25

申请号：US17106309

申请日：2020-11-30

申请人： CHEMOCENTRYX, INC.

发明人： Christopher Lange ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Yu Wang ,  Ju Yang ,  Penglie Zhang

IPC分类号： C07D207/12 ,  A61K45/06 ,  C07D401/12 ,  C07D207/267 ,  C07D211/44 ,  C07D403/12 ,  C07D211/38 ,  C07D451/06 ,  C07D205/12 ,  C07F5/02 ,  C07D405/14 ,  C07D401/14 ,  C07D471/10 ,  C07D211/76 ,  A61P37/02 ,  C07D205/04 ,  C07D213/85 ,  C07D295/088 ,  C07D487/10 ,  C07D405/12 ,  A61K31/40 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  C07D211/40 ,  C07D211/46

CPC分类号： C07D207/12 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4427 ,  A61K31/454 ,  A61K31/4545 ,  A61K45/06 ,  A61P37/02 ,  C07D205/04 ,  C07D205/12 ,  C07D207/267 ,  C07D211/38 ,  C07D211/40 ,  C07D211/44 ,  C07D211/46 ,  C07D211/76 ,  C07D213/85 ,  C07D295/088 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D451/06 ,  C07D471/10 ,  C07D487/10 ,  C07F5/025

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein Z, L, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11479553B2

公开(公告)日：2022-10-25

申请号：US16865648

申请日：2020-05-04

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61P37/02

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US10828285B2

公开(公告)日：2020-11-10

申请号：US16226865

申请日：2018-12-20

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61K31/437 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00 ,  A61K45/06

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US10562896B2

公开(公告)日：2020-02-18

申请号：US15991703

申请日：2018-05-29

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Rajinder Singh ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.