公开(公告)号：US11691985B2

公开(公告)日：2023-07-04

申请号：US17338502

申请日：2021-06-03

申请人： CHEMOCENTRYX, INC.

发明人： Viengkham Malathong ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Penglie Zhang

IPC分类号： C07D498/08 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

CPC分类号： C07D498/08 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II):






including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11266643B2

公开(公告)日：2022-03-08

申请号：US16874212

申请日：2020-05-14

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher Lange ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Viengkham Malathong ,  Sreenivas Punna ,  Rajinder Singh ,  Ju Yang ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D405/12 ,  A61K31/4985 ,  C07D471/04 ,  C07D401/12 ,  A61K31/506 ,  C07D403/12

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10759789B2

公开(公告)日：2020-09-01

申请号：US16524618

申请日：2019-07-29

申请人： CHEMOCENTRYX, INC.

发明人： Xi Chen ,  Dean R. Dragoli ,  Pingchen Fan ,  Manmohan Reddy Leleti ,  Rebecca M. Lui ,  Viengkham Malathong ,  Jay P. Powers ,  Rajinder Singh ,  Hiroko Tanaka ,  Ju Yang ,  Chao Yu ,  Penglie Zhang

IPC分类号： A61K31/404 ,  A61K31/4439 ,  C07D405/14 ,  C07D405/04 ,  C07D401/04 ,  C07D209/34 ,  A61P1/00 ,  A61P19/00 ,  A61P17/00 ,  A61P35/00 ,  A61P11/00

摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

公开(公告)号：US10683294B2

公开(公告)日：2020-06-16

申请号：US15991747

申请日：2018-05-29

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D487/04 ,  A61P37/02

摘要： The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US10342781B2

公开(公告)日：2019-07-09

申请号：US15659488

申请日：2017-07-25

申请人： CHEMOCENTRYX, INC.

发明人： Xi Chen ,  Dean R. Dragoli ,  Pingchen Fan ,  Juan C. Jaen ,  Yandong Li ,  Jay P. Powers ,  Viengkham Malathong ,  Sreenivas Punna ,  Hiroko Tanaka ,  Penglie Zhang

IPC分类号： A61K45/06 ,  A61K31/437 ,  C07D231/40 ,  C07D233/88 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196

摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

公开(公告)号：US20160296508A1

公开(公告)日：2016-10-13

申请号：US15074965

申请日：2016-03-18

申请人： ChemoCentryx, Inc.

发明人： Daniel Dairaghi ,  Dean R. Dragoli ,  Jarek Kalisiak ,  Christopher W. Lange ,  Manmohan Reddy Leleti ,  Yandong Li ,  Rebecca M. Lui ,  Venkat Reddy Mali ,  Viengkham Malathong ,  Jay P. Powers ,  Hiroko Tanaka ,  Joanne Tan ,  Matthew J. Walters ,  Ju Yang ,  Penglie Zhang

IPC分类号： A61K31/47 ,  A61K31/4709

CPC分类号： A61K31/47 ,  A61K31/4709 ,  C07D215/48 ,  C07D405/04 ,  C07D405/14

摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:

公开(公告)号：US11945805B2

公开(公告)日：2024-04-02

申请号：US17243872

申请日：2021-04-29

申请人： CHEMOCENTRYX, INC.

发明人： Xi Chen ,  Dean R. Dragoli ,  Junfa Fan ,  Jaroslaw Kalisiak ,  Manmohan Reddy Leleti ,  Viengkham Malathong ,  Jeffrey McMahon ,  Hiroko Tanaka ,  Ju Yang ,  Chao Yu ,  Penglie Zhang ,  Venkat Mali

IPC分类号： C07D405/12 ,  A61K31/4035 ,  A61K31/422 ,  A61K31/4439 ,  A61K45/06 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00 ,  A61P37/00 ,  C07B59/00 ,  C07D405/14 ,  C07D413/12

CPC分类号： C07D405/12 ,  A61K31/4035 ,  A61K31/422 ,  A61K31/4439 ,  A61K45/06 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00 ,  A61P37/00 ,  C07B59/002 ,  C07D405/14 ,  C07D413/12 ,  C07B2200/05 ,  A61K31/4035 ,  A61K2300/00 ,  A61K31/422 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00

摘要： Compounds are provided as inhibitors of CXCR2, having the structure:

公开(公告)号：US11773091B2

公开(公告)日：2023-10-03

申请号：US17735283

申请日：2022-05-03

申请人： CHEMOCENTRYX, INC.

发明人： Pingchen Fan ,  Christopher W. Lange ,  Rebecca M. Lui ,  Viengkham Malathong ,  Venkat Reddy Mali ,  Sreenivas Punna ,  Rajinder Singh ,  Hiroko Tanaka ,  Yibin Zeng ,  Penglie Zhang

IPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61P37/02 ,  C07D519/00

摘要： The present disclosure provides, inter alia, Compounds of Formula (I)




or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

公开(公告)号：US11485708B2

公开(公告)日：2022-11-01

申请号：US16905979

申请日：2020-06-19

申请人： CHEMOCENTRYX, INC.

发明人： Viengkham Malathong ,  Pingchen Fan ,  Christopher Lange ,  Venkat Reddy Mali ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Ju Yang ,  Penglie Zhang

IPC分类号： C07D217/04 ,  A61K45/06 ,  C07D401/12 ,  A61K31/4725 ,  C07C217/58 ,  A61K31/137 ,  C07D211/58 ,  A61K31/4468 ,  A61K31/4545 ,  C07C229/16 ,  A61K31/197 ,  C07D207/06 ,  A61K31/40 ,  C07D319/18 ,  A61K31/357 ,  C07D213/64 ,  A61K31/4402 ,  C07D215/227 ,  A61K31/4704 ,  C07C309/14 ,  A61K31/185 ,  A61K31/472

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11059834B2

公开(公告)日：2021-07-13

申请号：US16504536

申请日：2019-07-08

申请人： CHEMOCENTRYX, INC.

发明人： Viengkham Malathong ,  Jeffrey McMahon ,  Darren J. McMurtrie ,  Sreenivas Punna ,  Howard S. Roth ,  Rajinder Singh ,  Penglie Zhang

IPC分类号： C07D498/08 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.