- 专利标题： Tumor-selective CTLA-4 antagonists
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申请号： US16559561申请日： 2019-09-03
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公开(公告)号： US11279752B2公开(公告)日： 2022-03-22
- 发明人: John C. Williams , Ulrich Rodeck , Kurt Jenkins
- 申请人： City of Hope , Thomas Jefferson University
- 申请人地址： US CA Duarte; US PA Philadelphia
- 专利权人： City of Hope,Thomas Jefferson University
- 当前专利权人： City of Hope,Thomas Jefferson University
- 当前专利权人地址： US CA Duarte; US PA Philadelphia
- 代理机构： Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 主分类号： C07K14/82
- IPC分类号： C07K14/82 ; C07K16/28 ; C07K14/47 ; C07K14/705 ; C07K14/71 ; C12N9/64
摘要：
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4).
公开/授权文献
- US20200325212A1 TUMOR-SELECTIVE CTLA-4 ANTAGONISTS 公开/授权日：2020-10-15
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