公开(公告)号：US10414814B2

公开(公告)日：2019-09-17

申请号：US15322438

申请日：2015-07-02

申请人： City of Hope ,  Thomas Jefferson University

发明人： John C. Williams ,  Ulrich Rodeck ,  Kurt Jenkins

IPC分类号： C07K14/82 ,  C07K16/46 ,  C07K14/705 ,  C12N9/64 ,  C07K14/435 ,  C07K19/00 ,  C07K16/28 ,  C07K14/47 ,  C07K14/71

摘要： Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4).

公开(公告)号：US11926652B2

公开(公告)日：2024-03-12

申请号：US15931077

申请日：2020-05-13

申请人： City of Hope ,  Thomas Jefferson University and Health System, Innovation Pillar

发明人： John Williams ,  Ulrich Rodeck ,  Miso Park ,  Kurt Jenkins

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K47/64 ,  A61K47/65 ,  C07K14/705

CPC分类号： C07K14/4703 ,  A61K47/64 ,  A61K47/65 ,  C07K14/70521 ,  A61K38/00 ,  C07K2319/055 ,  C07K2319/30 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/74

摘要： Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.

公开(公告)号：US11279752B2

公开(公告)日：2022-03-22

申请号：US16559561

申请日：2019-09-03

申请人： City of Hope ,  Thomas Jefferson University

发明人： John C. Williams ,  Ulrich Rodeck ,  Kurt Jenkins

IPC分类号： C07K14/82 ,  C07K16/28 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C12N9/64

摘要： Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4).