- 专利标题： Bordetella vaccines comprising LPS with reduced reactogenicity
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申请号： US16493309申请日： 2018-03-13
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公开(公告)号： US11291713B2公开(公告)日： 2022-04-05
- 发明人: Peter André van der Ley , Jesús Andrés Arenas Busto , Elder Pupo Escalona , Johannes Petrus Maria Tommassen
- 申请人： De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- 申请人地址： NL The Hague
- 专利权人： De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- 当前专利权人： De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport
- 当前专利权人地址： NL The Hague
- 代理机构： N.V. Nederlandsch Octrooibureau
- 优先权： EP17160604 20170313
- 国际申请： PCT/EP2018/056241 WO 20180313
- 国际公布： WO2018/167061 WO 20180920
- 主分类号： A61K39/02
- IPC分类号： A61K39/02 ; A61P31/04 ; C12N1/20 ; C12N9/10 ; C12N9/14 ; A61K39/00
摘要：
The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.
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