发明授权
- 专利标题： Small molecule inhibitors of BCL-2-associated death promoter (BAD) phosphorylation
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申请号： US16605630申请日： 2018-04-18
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公开(公告)号： US11292773B2公开(公告)日： 2022-04-05
- 发明人: Peter Edward Lobie , Vijay Kumar Pandey , Rangappa Kanchugarakoppal Subbegowda , Bassappa Salundi , Mohan Chakrabhavi Dhananjaya , Shobith Rangappa , Srinivasa Venkatachalaiah
- 申请人： NATIONAL UNIVERSITY OF SINGAPORE , UNIVERSITY OF MYSORE , BANGALORE UNIVERSITY
- 申请人地址： SG Singapore; IN Mysore; IN Bangalore
- 专利权人： NATIONAL UNIVERSITY OF SINGAPORE,UNIVERSITY OF MYSORE,BANGALORE UNIVERSITY
- 当前专利权人： NATIONAL UNIVERSITY OF SINGAPORE,UNIVERSITY OF MYSORE,BANGALORE UNIVERSITY
- 当前专利权人地址： SG Singapore; IN Mysore; IN Bangalore
- 代理机构： Marshall, Gerstein & Borun LLP
- 优先权： GB1706162 20170419
- 国际申请： PCT/SG2018/050194 WO 20180418
- 国际公布： WO2018/194520 WO 20181025
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; A61P35/00 ; C07D405/06 ; C07D409/06 ; C07D413/04 ; C07D471/06 ; C07D213/53 ; C07D295/096 ; C07D295/155 ; C07D295/192 ; C07D307/52 ; C07D333/20 ; A61K31/495 ; A61K31/496
摘要：
The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.
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