公开(公告)号：US11141402B2

公开(公告)日：2021-10-12

申请号：US16619218

申请日：2018-06-05

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： Peter Edward Lobie ,  Vijay Kumar Pandey ,  Rangappa Kanchugarakoppal Subbegowda ,  Basappa ,  Mohan Chakrabhavi Dhananjaya ,  Shobith Rangappa

IPC分类号： A61K31/37 ,  A61K31/4433 ,  A61K45/06 ,  C07D493/04

摘要： Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.

公开(公告)号：US20160214968A1

公开(公告)日：2016-07-28

申请号：US15004114

申请日：2016-01-22

申请人： UNIVERSITY OF MYSORE ,  NATIONAL UNIVERSITY OF SINGAPORE ,  BANGALORE UNIVERSITY ,  CAMBRIDGE ENTERPRISE LTD

发明人： Kanchugarakoppal Subbegowda RANGAPPA ,  BASAPPA ,  Chakrabhavi Dhananjaya MOHAN ,  Shobith RANGAPPA ,  Hanumantharayappa BHARATHKUMAR ,  Gautam SETHI ,  Andreas BENDER ,  Peter Edward LOBIE ,  Kam Man HUI ,  Alan Prem KUMAR ,  Vijay Kumar PANDEY ,  Julian FUCHS ,  Muthu Kumaraswamy SHANMUGAM ,  Krishna BULUSU ,  Xiaoyun DAI ,  Feng LI ,  Amudha DEIVASIGAMANI

IPC分类号： C07D413/04 ,  C07D265/16

CPC分类号： C07D413/04 ,  C07D265/16

摘要： The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.

摘要翻译： 本公开涉及结构式I的化合物和制备所述化合物的方法。 本公开还涉及使用式I化合物调节癌细胞中Janus激酶 - 信号转导和转录激活因子（JAK-STAT）途径的方法，以及式I化合物作为抗癌剂的相应应用。

公开(公告)号：US11292773B2

公开(公告)日：2022-04-05

申请号：US16605630

申请日：2018-04-18

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： Peter Edward Lobie ,  Vijay Kumar Pandey ,  Rangappa Kanchugarakoppal Subbegowda ,  Bassappa Salundi ,  Mohan Chakrabhavi Dhananjaya ,  Shobith Rangappa ,  Srinivasa Venkatachalaiah

IPC分类号： C07D241/04 ,  A61P35/00 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D471/06 ,  C07D213/53 ,  C07D295/096 ,  C07D295/155 ,  C07D295/192 ,  C07D307/52 ,  C07D333/20 ,  A61K31/495 ,  A61K31/496

摘要： The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.

公开(公告)号：US09604974B2

公开(公告)日：2017-03-28

申请号：US15004114

申请日：2016-01-22

申请人： UNIVERSITY OF MYSORE ,  NATIONAL UNIVERSITY OF SINGAPORE ,  BANGALORE UNIVERSITY ,  CAMBRIDGE ENTERPRISE LTD

发明人： Kanchugarakoppal Subbegowda Rangappa ,  Basappa ,  Chakrabhavi Dhananjaya Mohan ,  Shobith Rangappa ,  Hanumantharayappa Bharathkumar ,  Gautam Sethi ,  Andreas Bender ,  Peter Edward Lobie ,  Kam Man Hui ,  Alan Prem Kumar ,  Vijay Kumar Pandey ,  Julian Fuchs ,  Muthu Kumaraswamy Shanmugam ,  Krishna Bulusu ,  Xiaoyun Dai ,  Feng Li ,  Amudha Deivasigamani

IPC分类号： C07D413/04 ,  C07D265/16

CPC分类号： C07D413/04 ,  C07D265/16

摘要： The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.

公开(公告)号：US20200147039A1

公开(公告)日：2020-05-14

申请号：US16619218

申请日：2018-06-05

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： Peter Edward LOBIE ,  Vijay Kumar PANDEY ,  Rangappa KANCHUGARAKOPPALSUBBEGOWDA ,  Basappa BASAPPA ,  Mohan CHAKRABHAVI DHANANJAYA ,  Shobith RANGAPPA

IPC分类号： A61K31/37 ,  A61K45/06 ,  C07D493/04 ,  A61K31/4433

摘要： Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.