Invention Grant
- Patent Title: Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
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Application No.: US16125699Application Date: 2018-09-08
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Publication No.: US11306290B2Publication Date: 2022-04-19
- Inventor: Irina Kerkis , Cristiane Valverde Wenceslau
- Applicant: AVITA INTERNATIONAL LTD. , FUNDAÇ ÃO BUTANTAN
- Applicant Address: VG Tortola; BR São Paulo
- Assignee: AVITA INTERNATIONAL LTD.,FUNDAÇ ÃO BUTANTAN
- Current Assignee: AVITA INTERNATIONAL LTD.,FUNDAÇ ÃO BUTANTAN
- Current Assignee Address: VG Tortola; BR São Paulo
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- Main IPC: C12N5/0775
- IPC: C12N5/0775 ; A61K35/32 ; A61K9/00 ; C07K14/705 ; A61P35/00 ; A61P25/00 ; A61K35/28 ; C12N5/0793 ; C12N5/079
Abstract:
The invention provides a method of producing human immature dental pulp stem cells (hIDPSCs) expressing CD44 and CD13 and lacking expression of CD146. The invention also provides compositions for use in the treatment of a neurological disease or condition selected from the group consisting of Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis (ALS), stroke, autoimmune encephalomyelitis, diabetic neuropathy, glaucomatous neuropathy, Alzheimer's disease, Huntington's disease (HD), autism, schizophrenia, stroke, ischemia, a motor disorder, and a convulsive disorder.
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