- 专利标题： Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
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申请号： US16125699申请日： 2018-09-08
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公开(公告)号： US11306290B2公开(公告)日： 2022-04-19
- 发明人: Irina Kerkis , Cristiane Valverde Wenceslau
- 申请人： AVITA INTERNATIONAL LTD. , FUNDAÇ ÃO BUTANTAN
- 申请人地址： VG Tortola; BR São Paulo
- 专利权人： AVITA INTERNATIONAL LTD.,FUNDAÇ ÃO BUTANTAN
- 当前专利权人： AVITA INTERNATIONAL LTD.,FUNDAÇ ÃO BUTANTAN
- 当前专利权人地址： VG Tortola; BR São Paulo
- 代理机构： Booth Udall Fuller, PLC
- 代理商 Rodney J. Fuller
- 主分类号： C12N5/0775
- IPC分类号： C12N5/0775 ; A61K35/32 ; A61K9/00 ; C07K14/705 ; A61P35/00 ; A61P25/00 ; A61K35/28 ; C12N5/0793 ; C12N5/079
摘要：
The invention provides a method of producing human immature dental pulp stem cells (hIDPSCs) expressing CD44 and CD13 and lacking expression of CD146. The invention also provides compositions for use in the treatment of a neurological disease or condition selected from the group consisting of Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis (ALS), stroke, autoimmune encephalomyelitis, diabetic neuropathy, glaucomatous neuropathy, Alzheimer's disease, Huntington's disease (HD), autism, schizophrenia, stroke, ischemia, a motor disorder, and a convulsive disorder.
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