An electronic device may include a housing and four antennas at respective corners of the housing. Cellular telephone transceiver circuitry may concurrently convey signals at one or more of the same frequencies over one or more of the four antennas using a multiple-input multiple-output (MIMO) scheme. In order to isolate adjacent antennas, dielectric-filled openings may be formed in conductive walls of the housing to divide the walls into segments that are used to form resonating element arms for the antennas. If desired, first and second antennas may include resonating element arms formed from a wall without any gaps. The first and second antennas may include adjacent return paths. A magnetic field associated with currents for the first antenna may cancel out with a magnetic field associated with currents for the second antenna at the adjacent return paths, thereby serving to electromagnetically isolate the first and second antennas.