- 专利标题： Monooxygenase and use in preparation of optically pure sulfoxide
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申请号： US17294424申请日： 2019-11-26
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公开(公告)号： US11345900B2公开(公告)日： 2022-05-31
- 发明人: Yan Zhang , Huilei Yu , Shimiao Ren , Peng Zhao , Jianhe Xu , Yinqi Wu , Qian Zhao
- 申请人： JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
- 申请人地址： CN Nanjing; CN Shanghai
- 专利权人： JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.,EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
- 当前专利权人： JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.,EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
- 当前专利权人地址： CN Nanjing; CN Shanghai
- 代理机构： Bayramoglu Law Offices LLC
- 优先权： CN201811420321.1 20181126
- 国际申请： PCT/CN2019/120798 WO 20191126
- 国际公布： WO2020/108462 WO 20200604
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12P17/14 ; C12P17/16
摘要：
A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
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