专利检索 ap:("JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD." OR "EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY") AND inv:"Yinqi Wu" 第 1 页

1.

发明授权
Monooxygenase and use in preparation of optically pure sulfoxide 有权

公开(公告)号：US11345900B2

公开(公告)日：2022-05-31

申请号：US17294424

申请日：2019-11-26

申请人： JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Yan Zhang , Huilei Yu , Shimiao Ren , Peng Zhao , Jianhe Xu , Yinqi Wu , Qian Zhao

IPC分类号： C12N9/02 , C12P17/14 , C12P17/16

摘要： A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.