A system and method that provides inter-application relevance management for resources being brokered by an application virtualization platform. A described platform includes a memory configured to store a set of relevance rules for applications hosted by the application virtualization platform, wherein each relevance rule specifies a relevance setting between a first application and a second application. Also included is a processor coupled to the memory and configured to broker resources for the application virtualization platform, according to a method. The method includes: receiving a request from a client to launch a target application hosted by the application virtualization platform; retrieving a subset of applicable relevance rules that specify the target application from the set of relevance rules; and selecting a resource for the target application based on the subset of applicable relevance rules, wherein the resource includes at least one of a session or a session server.