The present disclosure is directed to systems and methods of optimizing display image quality on display devices having a plurality of display power modes. An example apparatus includes processor circuitry to execute instructions to: determine a baseline allowable percentage of distorted pixels for a power mode of a display; determine a baseline first relationship between an original pixel value and a boosted pixel value for the power mode; determine a baseline second relationship based on the baseline allowable percentage and the baseline first relationship; select a plurality of test distorted pixel percentages; determine, for respective selected test distorted pixel percentages, a corresponding test relationship between an original pixel color value distribution and a boosted pixel color value distribution based on the baseline second relationship; determine, for respective test relationships, a respective test peak signal to noise ratio (PSNR); determine, for the respective test PSNRs, respective values indicative of the change in image quality for the test distorted pixel percentages; and select, as the operating distorted original pixel percentage value, one of the test distorted pixel percentages based on the values.