- Patent Title: Compositions and methods for making and using thermostable immunogenic formulations with increased compatibility of use as vaccines against one or more pathogens
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Application No.: US16909689Application Date: 2020-06-23
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Publication No.: US11364293B2Publication Date: 2022-06-21
- Inventor: Theodore W. Randolph , Robert Garcea , Alan W. Weimer
- Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
- Applicant Address: US CO Denver
- Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
- Current Assignee Address: US CO Denver
- Agency: Polsinelli PC
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; G01N27/74 ; A61K47/10 ; A61K48/00 ; A61K39/12 ; A61K9/50 ; A61K39/02 ; A61K39/39 ; A61K39/00

Abstract:
Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.
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