公开(公告)号：US20190046632A1

公开(公告)日：2019-02-14

申请号：US16079507

申请日：2017-02-23

Applicant: The Regents of the University of Colorado, a body Corporate

Inventor： Theodore W. Randolph ,  Robert Garcea ,  Alan W. Weimer

IPC: A61K39/12 ,  A61K9/50 ,  A61K39/02 ,  A61K39/39

CPC classification number: A61K39/12 ,  A61K9/5015 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/60 ,  C12N2710/20034 ,  C12N2770/24134

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.

公开(公告)号：US20170065707A1

公开(公告)日：2017-03-09

申请号：US15309169

申请日：2015-05-06

Applicant: The Regents of the University of Colorado, A body corporate

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K45/06

CPC classification number: A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N2710/20034 ,  C12N2710/20063

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

Abstract translation: 本发明的实施方案提供了用于制备和使用热稳定的人乳头瘤病毒（HPV）制剂或其它稳定的多聚体病毒制剂的新型组合物和方法。 某些实施方案涉及在存在或不存在佐剂的情况下冻干HPV制剂。 其他实施方案涉及使用HPV疫苗疫苗，以提高免疫原性组合物对于HPV感染的储存，递送和使用的稳定性。 在其它实施方案中，单个免疫原性组合物可以包括多种病毒血清型的热稳定制剂。

公开(公告)号：US20220370592A1

公开(公告)日：2022-11-24

申请号：US17817591

申请日：2022-08-04

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US20190184001A1

公开(公告)日：2019-06-20

申请号：US16192717

申请日：2018-11-15

Applicant: The Regents of the University of Colorado, A body corporate

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

CPC classification number: A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N2710/20034 ,  C12N2710/20063

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US20240130973A1

公开(公告)日：2024-04-25

申请号：US18372556

申请日：2023-09-24

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea

IPC: A61K9/19 ,  A61K9/16 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00

CPC classification number: A61K9/19 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00 ,  A61K2039/5258

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US20230293662A1

公开(公告)日：2023-09-21

申请号：US18069058

申请日：2022-12-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

CPC classification number: A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US11364293B2

公开(公告)日：2022-06-21

申请号：US16909689

申请日：2020-06-23

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO

Inventor： Theodore W. Randolph ,  Robert Garcea ,  Alan W. Weimer

IPC: C12Q1/68 ,  C07H21/04 ,  G01N27/74 ,  A61K47/10 ,  A61K48/00 ,  A61K39/12 ,  A61K9/50 ,  A61K39/02 ,  A61K39/39 ,  A61K39/00

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.

公开(公告)号：US11273127B2

公开(公告)日：2022-03-15

申请号：US16146686

申请日：2018-09-28

Applicant: The Regents of the University of Colorado, A body corporate

Inventor： Theodore Randolph ,  Robert Garcea

IPC: A61K9/19 ,  A61K9/16 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US12186384B2

公开(公告)日：2025-01-07

申请号：US17741894

申请日：2022-05-11

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore W. Randolph ,  Robert Garcea ,  Alan W. Weimer

IPC: A61K39/12 ,  A61K9/19 ,  A61K9/50 ,  A61K39/00 ,  A61K39/02 ,  A61K39/39 ,  A61K48/00

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens. In other embodiments, incompatible immunogenic agents against two or more different pathogens of immunogenic agent-containing particles disclosed herein can be mixed together and coated for timed-release administration to produce single-administration formulations capable of eliciting an immune response to the two or more pathogens in a subject.

公开(公告)号：US20240245612A1

公开(公告)日：2024-07-25

申请号：US18627155

申请日：2024-04-04

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Theodore Randolph ,  Alyssa Witeof ,  Robert Garcea

IPC: A61K9/50 ,  A61K9/48 ,  A61K39/00 ,  A61K39/385

CPC classification number: A61K9/501 ,  A61K9/4858 ,  A61K39/385 ,  A61K2039/54

Abstract: Embodiments of the instant disclosure generally relate to novel compositions, methods, and systems for reducing or eliminating effects of interfering agents or premature dissolution of antigen-containing microparticles during storage, transport, and delivery of antigen-containing formulations. Certain embodiments concern improved formulations for more reliable storage, transport, delivery, and administration of metal oxide coated antigen-containing suspension formulations.