公开(公告)号：US12297851B2

公开(公告)日：2025-05-13

申请号：US18138621

申请日：2023-04-24

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Christoph Matthias Keplinger ,  Xingrui Wang ,  Shane Karl Mitchell

IPC: F15B15/10 ,  B25J9/10 ,  F15B5/00 ,  F15B21/06

Abstract: High strain hydraulically amplified self-healing electrostatic transducers having increased maximum theoretical and practical strains are disclosed. In particular, the actuators include electrode configurations having a zipping front created by the attraction of the electrodes that is configured orthogonally to a strain axis along which the actuators. This configuration produces increased strains. In turn, various form factors for the actuator configuration are presented including an artificial circular muscle and a strain amplifying pulley system. Other actuator configurations are contemplated that include independent and opposed electrode pairs to create cyclic activation, hybrid electrode configurations, and use of strain limiting layers for controlled deflection of the actuator.

公开(公告)号：US12290716B2

公开(公告)日：2025-05-06

申请号：US18206022

申请日：2023-06-05

Applicant: The Regents of the University of Colorado

Inventor： Elizabeth Cuadrado ,  Aaron Treat ,  Joshua W. Morrison ,  Robert Elliott

IPC: A63B23/03 ,  A63B21/00 ,  A63B21/008

Abstract: Disclosed is a tongue strengthening device that includes a handle on one end and a bulb structure on the other end. The bulb is resiliently flexible, and enables a user to exercise their tongue by repeatedly compressing and releasing the bulb. Provided is a system or kit that includes multiple tongue strengthening devices having different compression specifications that allow a patient to graduate to devices which are harder to compress as the patient gains tongue strength.

公开(公告)号：US12286615B2

公开(公告)日：2025-04-29

申请号：US18208548

申请日：2023-06-12

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Xiaoyun Ding ,  Apresio Kefin Fajrial

IPC: C12M1/34 ,  C12M1/26 ,  C12M3/06 ,  C12N15/89 ,  C12M1/42 ,  C12N5/16

Abstract: The invention relates to a microfluidic poration device having narrow channels slightly smaller than the width of a target cell, wherein the channels are lined with a plurality of nanospikes in a row extending down the middle of the channel, i.e. in a row parallel to the sides of the channel. In one embodiment, one channel may have 2 nanospikes (or 2 nanolancets). Thus, in particular embodiments, the invention provides microfluidic poration devices capable of simultaneously squeezing cells while piercing holes in their membranes for allowing foreign molecules into cells. The holes in porated cells spontaneously close after exiting the channels, thus entrapping the foreign molecules inside of the target cells. This porated cell population has approximately a 95% viability with greater than 50% containing at least one foreign molecule.

公开(公告)号：US20250127777A1

公开(公告)日：2025-04-24

申请号：US18999868

申请日：2024-12-23

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： Zdenek ANDRYSIK ,  Joaquin Maximiliano ESPINOSA

IPC: A61K31/496 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/47 ,  A61P35/00

Abstract: A pharmaceutical combination having one or more MDM2 inhibitor and one or more inhibitor of dephosphorylation of elF2α. MDM2 inhibitors are non-peptide small molecule inhibitors or stapled peptide inhibitors of the interaction between MDM2 and p53. Inhibitors of phosphorylation of elF2α are non-peptide small molecule inhibitors. Components of the pharmaceutical combination are administered to a subject in need thereof in a combined therapeutic amount to provide therapeutic effect and optionally synergistic therapeutic effect. A method for treatment of proliferative disease or disorders, including various cancers, which comprises administering to a subject in need thereof of one or more MDM2 inhibitor and one or more inhibitor of dephosphorylation of elF2α, wherein the inhibitors are administered in a combined therapeutic amount to provide therapeutic effect and optionally synergistic therapeutic effect.

公开(公告)号：US20250116601A1

公开(公告)日：2025-04-10

申请号：US18730240

申请日：2023-01-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Gregory B. RIEKER ,  Charles Scott CALLAHAN

IPC: G01N21/39 ,  G01N33/00

Abstract: A method for spectroscopic gas sensing processes a measured spectrum generated by an optical spectrometer. The method includes transforming, with a locality-sensitive hash function, the measured spectrum into an integer hash value h. The method also includes adding, to a candidate set of candidate spectra, template spectra stored in an hth bin of a look-up table. The method also includes calculating, based on each candidate spectrum in the candidate set, a measure that quantifies discrepancy between the measured spectrum and said each candidate spectrum. The method also includes identifying, based on the measure, a best-match spectrum of the candidate spectra, and retrieving, from the hth bin of the look-up table, a parameter set corresponding to the best-match spectrum. The method also includes deriving, based on the parameter set, one or more properties of the gas sample.

公开(公告)号：US20250114452A1

公开(公告)日：2025-04-10

申请号：US18294650

申请日：2022-08-04

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： Mark KOHLER ,  Catherine DANIS ,  Terry J. FRY ,  Lillie LEACH

IPC: A61K40/11 ,  A61K40/31 ,  A61K40/42 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

Abstract: The disclosure describes T cells that express chimeric antigen receptors (CARs), as well as pharmaceutical compositions comprising T cells and methods of making and using such T cells. Particularly, this disclosure describes T cells expressing a first CAR that binds to a first antigen and a second CAR comprising a LAT intracellular signaling domain that binds to a second antigen, and methods of use in treating cancers, such as solid tumors and hematological malignancies.

公开(公告)号：US20250101131A1

公开(公告)日：2025-03-27

申请号：US18656832

申请日：2024-05-07

Applicant: The Regents of the University of Colorado, a Body Corporate ,  Konkuk University Industry Cooperation Foundation

Inventor： Charles A. Dinarello ,  Soohyun Kim

IPC: C07K16/40 ,  A61K38/57 ,  C07K14/81 ,  C12N15/62

Abstract: Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment.

公开(公告)号：US12248105B2

公开(公告)日：2025-03-11

申请号：US18132897

申请日：2023-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate ,  LiteWave Technologies, Inc.

Inventor： Jeffrey P. Thayer ,  Andrew W. Gisler ,  Steven Mitchell ,  Matthew Hayman

IPC: G01C3/08 ,  G01C13/00 ,  G01S7/499 ,  G01S17/10 ,  G01S17/89

Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.

公开(公告)号：US12241013B2

公开(公告)日：2025-03-04

申请号：US17615021

申请日：2020-05-28

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Timothy White ,  Brian Richard Donovan

IPC: C09K19/54 ,  C09K19/04

Abstract: Isotropic (amorphous) elastomers and methods of preparation are described. The isotropic elastomer may include a first monomer having an alkene functionality and a second monomer having a thiol functionality. The first monomer may be a liquid crystal monomer and the second monomer may be an isotropic monomer. Unlike polydomain LCEs, the isotropic elastomers may rapidly recover after deformation and have increased toughness relative to conventional elastomers prepared from wholly isotropic precursors.

公开(公告)号：US20250059546A1

公开(公告)日：2025-02-20

申请号：US18925537

申请日：2024-10-24

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE

Inventor： Brian DEDECKER ,  Simon KALMUS ,  David BIRKHAEUSER ,  Nickles BADGER

IPC: C12N15/113 ,  C12N15/82

Abstract: Systems, methods and compositions for the inducible production of squalene in plants seeds, in part by downregulating the endogenous sterol production pathway, for example through heterologous expression of one or more inhibitory RNA molecules, and in a preferred embodiment a novel hairpin multiple RNAi molecules that target paralogs of squalene epoxidase (SQE). Downregulating SQE causes a buildup of squalene by both blocking downstream conversion of squalene into sterols and releasing the negative feedback loop that sterols have with the upstream MVA pathway.