Invention Grant
- Patent Title: Methods for modifying human antibodies by glycan engineering
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Application No.: US16150164Application Date: 2018-10-02
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Publication No.: US11377485B2Publication Date: 2022-07-05
- Inventor: Chi-Huey Wong , Chung-Yi Wu
- Applicant: Academia Sinica
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Ladas & Parry LLP
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C12P21/00 ; C07K16/28

Abstract:
Methods for making modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Antibodies comprising Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.
Public/Granted literature
- US20190194303A1 METHODS FOR MODIFYING HUMAN ANTIBODIES BY GLYCAN ENGINEERING Public/Granted day:2019-06-27
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