Invention Grant
- Patent Title: Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
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Application No.: US16641604Application Date: 2018-08-24
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Publication No.: US11407763B2Publication Date: 2022-08-09
- Inventor: Jin Hee Ahn , Hail Kim , Jaemyoung Suh , In-Kyu Lee , Kwang-eun Kim , Kun-Young Park , Eun Jung Bae , Ko Eun Shong , Suvarna Haus-habhau Pagire , Ajin Lim , Jae-Han Jeon , Haushabhau Shivaji Pagire , Haiying Zhang , Myung-Hwa Kim , Jung-In Pyo
- Applicant: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY , KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , CURACLE CO., LTD.
- Applicant Address: KR Gwangju; KR Daejeon; KR Daegu; KR Seongnam-si
- Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY,KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY,KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,CURACLE CO., LTD.
- Current Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY,KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY,KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,CURACLE CO., LTD.
- Current Assignee Address: KR Gwangju; KR Daejeon; KR Daegu; KR Seongnam-si
- Agency: Workman Nydegger
- Priority: KR10-2017-0106983 20170824
- International Application: PCT/KR2018/009796 WO 20180824
- International Announcement: WO2019/039905 WO 20190228
- Main IPC: C07D495/04
- IPC: C07D495/04 ; C07D487/04 ; C07D403/12 ; C07D403/14 ; C07D271/06 ; C07D231/12 ; C07D401/14 ; C07D401/12 ; C07D239/47 ; C07D405/12 ; C07D403/08 ; A61P35/00 ; A61P1/00 ; C07D405/14
Abstract:
The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.
Public/Granted literature
- US20210155634A1 NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Public/Granted day:2021-05-27
Information query
