Invention Grant
- Patent Title: Methods of identifying bacteria comprising binding polypeptides
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Application No.: US15782616Application Date: 2017-10-12
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Publication No.: US11434482B2Publication Date: 2022-09-06
- Inventor: Twyla Noelle Lombana , Rebekah McKenna , Christoph Spiess , Karthik Veeravalli , Michael Dillon
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Thomas J. Takara
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12N15/10 ; C07K16/22 ; C07K16/24 ; C07K14/195 ; C07K16/12 ; C12Q1/689 ; G01N33/569 ; G01N33/68
Abstract:
The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.
Public/Granted literature
- US20180030434A1 METHODS OF IDENTIFYING BACTERIA COMPRISING BINDING POLYPEPTIDES Public/Granted day:2018-02-01
Information query
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