- 专利标题： Anti-thyroglobulin T cell receptors
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申请号： US16586310申请日： 2019-09-27
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公开(公告)号： US11440956B2公开(公告)日： 2022-09-13
- 发明人: Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 主分类号： C07K16/26
- IPC分类号： C07K16/26 ; C07K14/725 ; A61P35/04 ; A61P35/00 ; A61K38/00
摘要：
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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