-
公开(公告)号：US20130195819A1
公开(公告)日：2013-08-01
申请号：US13851473
申请日：2013-03-27
发明人： Qiong J. Wang , Kenichi Hanada , James C. Yang
IPC分类号： C07K14/705 , G01N33/68 , A61K35/14 , C12Q1/68
CPC分类号： C07K14/70503 , A61K35/17 , A61K38/00 , C07K14/7051 , C12Q1/6886 , G01N33/6893
摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
摘要翻译： 本发明提供了对癌症抗原（例如肾细胞癌抗原）具有抗原特异性的分离或纯化的T细胞受体（TCR），其中TCR以主要组织相容性复合体（MHC）为依赖性识别癌抗原。 还提供了相关多肽，蛋白质，核酸，重组表达载体，分离的宿主细胞，细胞群，抗体或其抗原结合部分，以及药物组合物。 本发明还提供了检测宿主中癌症存在的方法以及使用本发明的TCR或相关材料治疗或预防宿主中的癌症的方法。
-
公开(公告)号：US20220389093A1
公开(公告)日：2022-12-08
申请号：US17817599
申请日：2022-08-04
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
-
公开(公告)号：US20200317807A1
公开(公告)日：2020-10-08
申请号：US16906061
申请日：2020-06-19
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： C07K16/30 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , A61P35/00
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
-
公开(公告)号：US10450372B2
公开(公告)日：2019-10-22
申请号：US15524869
申请日：2015-11-12
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00 , A61K38/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
-
公开(公告)号：US20230138309A1
公开(公告)日：2023-05-04
申请号：US17912315
申请日：2021-03-19
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Sri Krishna , Frank J. Lowery, III , Ken-ichi Hanada , James C. Yang , Steven A. Rosenberg , Paul F. Robbins , Rami Yoseph
IPC分类号： C12N15/10 , C12N5/0783 , C12Q1/6881
摘要： Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a tumor sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a T cell receptor (TCR), preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.
-
公开(公告)号：US20210115108A1
公开(公告)日：2021-04-22
申请号：US17051860
申请日：2019-05-01
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Kenichi Hanada , Chihao Zhao , Anna Pasetto , James C. Yang
IPC分类号： C07K14/725 , G01N33/574 , A61K35/17
摘要： Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated EGFR amino acid sequence with a E746-A750 deletion. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
-
公开(公告)号：US11999796B2
公开(公告)日：2024-06-04
申请号：US16906061
申请日：2020-06-19
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： A61K35/17 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K16/30 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/7153 , C07K16/2875 , A61K35/17 , C07K2317/60 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
-
公开(公告)号：US11440956B2
公开(公告)日：2022-09-13
申请号：US16586310
申请日：2019-09-27
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00 , A61K38/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
-
公开(公告)号：US09567387B2
公开(公告)日：2017-02-14
申请号：US13851473
申请日：2013-03-27
发明人： Qiong J. Wang , Kenichi Hanada , James C. Yang
IPC分类号： G01N33/49 , C07K14/705 , C07K14/725 , A61K35/17 , C12Q1/68 , G01N33/68 , A61K38/00
CPC分类号： C07K14/70503 , A61K35/17 , A61K38/00 , C07K14/7051 , C12Q1/6886 , G01N33/6893
摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
摘要翻译： 本发明提供了对癌症抗原（例如肾细胞癌抗原）具有抗原特异性的分离或纯化的T细胞受体（TCR），其中TCR以主要组织相容性复合体（MHC）为依赖性识别癌抗原。 还提供了相关多肽，蛋白质，核酸，重组表达载体，分离的宿主细胞，细胞群，抗体或其抗原结合部分，以及药物组合物。 本发明还提供了检测宿主中癌症存在的方法以及使用本发明的TCR或相关材料治疗或预防宿主中的癌症的方法。
-
公开(公告)号：US20220088164A1
公开(公告)日：2022-03-24
申请号：US17535318
申请日：2021-11-24
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： A61K39/00 , C07K14/725 , C07K14/82 , G01N33/574
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.029 秒)
