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公开(公告)号：US11999796B2
公开(公告)日：2024-06-04
申请号：US16906061
申请日：2020-06-19
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： A61K35/17 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K16/30 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/7153 , C07K16/2875 , A61K35/17 , C07K2317/60 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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公开(公告)号：US11440956B2
公开(公告)日：2022-09-13
申请号：US16586310
申请日：2019-09-27
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00 , A61K38/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20220389093A1
公开(公告)日：2022-12-08
申请号：US17817599
申请日：2022-08-04
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20200317807A1
公开(公告)日：2020-10-08
申请号：US16906061
申请日：2020-06-19
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： C07K16/30 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , A61P35/00
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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公开(公告)号：US10450372B2
公开(公告)日：2019-10-22
申请号：US15524869
申请日：2015-11-12
发明人： Kenichi Hanada , Qiong J. Wang , James C. Yang , Zhiya Yu
IPC分类号： C07K16/26 , C07K14/725 , A61P35/04 , A61P35/00 , A61K38/00
摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US09522948B2
公开(公告)日：2016-12-20
申请号：US14106031
申请日：2013-12-13
IPC分类号： C07H21/02 , C12N15/00 , C07K14/705 , C07K14/725 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/574 , A61K38/00
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
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公开(公告)号：US20220088164A1
公开(公告)日：2022-03-24
申请号：US17535318
申请日：2021-11-24
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： A61K39/00 , C07K14/725 , C07K14/82 , G01N33/574
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US11207394B2
公开(公告)日：2021-12-28
申请号：US15528813
申请日：2015-11-24
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： C07K14/725 , A61K39/00 , C07K14/82 , G01N33/574 , A61K38/00
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US10689456B2
公开(公告)日：2020-06-23
申请号：US15531626
申请日：2015-04-09
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： A61K35/17 , C07K16/30 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , A61P35/00
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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