Invention Grant
- Patent Title: Induction of a physiological dispersion response in bacterial cells in a biofilm
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Application No.: US15931561Application Date: 2020-05-13
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Publication No.: US11452291B2Publication Date: 2022-09-27
- Inventor: David G. Davies
- Applicant: The Research Foundation for The State University of New York
- Applicant Address: US NY Binghamton
- Assignee: The Research Foundation for The State University of New York
- Current Assignee: The Research Foundation for The State University of New York
- Current Assignee Address: US NY Binghamton
- Agency: Hoffberg & Associates
- Agent Steven M. Hoffberg
- Main IPC: A01N37/06
- IPC: A01N37/06 ; A61Q11/00 ; A01N37/02 ; A61K8/36 ; A01N37/18 ; A61K8/49 ; G02B1/04

Abstract:
One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising: H3C—(CH2)n—CHmCHmR, where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.
Public/Granted literature
- US20200275653A1 INDUCTION OF A PHYSIOLOGICAL DISPERSION RESPONSE IN BACTERIAL CELLS IN A BIOFILM Public/Granted day:2020-09-03
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