Embodiments of the present disclosure disclose a method, apparatus, device, and storage medium for controlling a guide robot, and relate to the field of artificial intelligence, robots, and multi-sensor fusion technologies. A specific embodiment of the method includes: acquiring a state of the guide robot, a state of a user, and a position of an obstacle; generating a state update equation for a combined system of the guide robot and the user based on the state of the guide robot and the state of the user; generating a collision-free global path based on the position of the obstacle; generating a control command based on the state update equation for the combined system and the collision-free global path; and driving the guide robot to move based on the control command.