- 专利标题: Engineered phagemids
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申请号: US15780668申请日: 2015-12-04
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公开(公告)号: US11473104B2公开(公告)日: 2022-10-18
- 发明人: Russell-John Krom , James J. Collins , Prerna Saluja Bhargava , Michael Andrew Lobritz
- 申请人: Massachusetts Institute of Technology , Trustees of Boston University , President and Fellows of Harvard College
- 申请人地址: US MA Cambridge; US MA Boston; US MA Cambridge
- 专利权人: Massachusetts Institute of Technology,Trustees of Boston University,President and Fellows of Harvard College
- 当前专利权人: Massachusetts Institute of Technology,Trustees of Boston University,President and Fellows of Harvard College
- 当前专利权人地址: US MA Cambridge; US MA Boston; US MA Cambridge
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 国际申请: PCT/US2015/064020 WO 20151204
- 国际公布: WO2017/095440 WO 20170608
- 主分类号: C12N15/86
- IPC分类号: C12N15/86 ; A61K35/76 ; C07K14/245 ; C07K14/35 ; C12N15/63 ; C12N15/70 ; C12N15/74 ; C07K14/46 ; C07K14/435 ; C07K14/61
摘要:
Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.
公开/授权文献
- US20180355378A1 ENGINEERED PHAGEMIDS 公开/授权日:2018-12-13