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公开(公告)号：US11473104B2
公开(公告)日：2022-10-18
申请号：US15780668
申请日：2015-12-04
申请人： Massachusetts Institute of Technology , Trustees of Boston University , President and Fellows of Harvard College
IPC分类号： C12N15/86 , A61K35/76 , C07K14/245 , C07K14/35 , C12N15/63 , C12N15/70 , C12N15/74 , C07K14/46 , C07K14/435 , C07K14/61
摘要： Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.
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公开(公告)号：US20180305703A1
公开(公告)日：2018-10-25
申请号：US15924045
申请日：2018-03-16
CPC分类号： C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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公开(公告)号：US10968454B2
公开(公告)日：2021-04-06
申请号：US15924045
申请日：2018-03-16
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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公开(公告)号：US20220033830A1
公开(公告)日：2022-02-03
申请号：US17189113
申请日：2021-03-01
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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公开(公告)号：US20150004705A1
公开(公告)日：2015-01-01
申请号：US14320965
申请日：2014-07-01
IPC分类号： C12N15/74
CPC分类号： C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
摘要翻译： 本公开的各个方面和实施方案涉及在体内功能化内源性细菌的方法和组合物。 所述方法包括向内源细菌细胞递送重组噬菌体或被设计成含有至少一个遗传回路的噬菌粒。
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公开(公告)号：US09957511B2
公开(公告)日：2018-05-01
申请号：US14320965
申请日：2014-07-01
CPC分类号： C12N15/74 , C12N7/00 , C12N15/70 , C12N2795/14132 , C12N2795/14143 , C12N2795/14171 , C12N2830/55
摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
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