Computer-implemented methods and systems are provided for curating medical images for a medical image database. An example method for curating involves operating a processor to obtain a query medical image, assign the query medical image to an initial set of related images, and generate a similarity indicator for each image of the initial set. The similarity indicator is representative of a measure of similarity between image data of that image and the initial set. The processor is operable to define an intermediate set from the initial set based on the similarity indicators; and generate a relevancy indicator for each image of the intermediate set. The relevancy indicator is representative of a measure of the relevancy between relevance of the image and the intermediate set. The processor is operable to define a curated set of images from the intermediate set based on the relevancy indicators.