Physically unclonable functions response in memory cells is improved by transistor sizing, transistor threshold voltage (VT) and body bias in the memory cell to improve the reproducibility of the memory cell and multiple Sense Amplifiers (SA) per column to further enhance physically unclonable function entropy. A physically unclonable function exploits a large number of read-sequence-order combinations available in a physically unclonable function memory array to generate an exponentially large challenge-response pair space, without incurring the area and energy costs of hosting and operating an exponentially large memory array.