Invention Grant
- Patent Title: 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
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Application No.: US16639145Application Date: 2018-08-16
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Publication No.: US11498903B2Publication Date: 2022-11-15
- Inventor: Shun Su , Hannguang J. Chao , Adam James Clarke , R. Michael Lawrence
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu; Shrikant M. Kulkarni
- International Application: PCT/US2018/000311 WO 20180816
- International Announcement: WO2019/036024 WO 20190221
- Main IPC: C07D235/16
- IPC: C07D235/16 ; C07D413/12 ; C07D413/10 ; C07D471/04 ; C07D491/056 ; C07D473/00 ; C07D235/18
Abstract:
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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