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公开(公告)号:US11498903B2
公开(公告)日:2022-11-15
申请号:US16639145
申请日:2018-08-16
IPC分类号: C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
摘要: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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公开(公告)号:US20200231547A1
公开(公告)日:2020-07-23
申请号:US16639145
申请日:2018-08-16
IPC分类号: C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
摘要: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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