发明授权
- 专利标题: Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
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申请号: US16760345申请日: 2018-10-30
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公开(公告)号: US11505559B2公开(公告)日: 2022-11-22
- 发明人: Shyh Ming Yang , David J. Maloney , Natalia Martinez , Adam Yasgar , Anton Simeonov , Vasilis Vasiliou
- 申请人: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , YALE UNIVERSITY
- 申请人地址: US MD Bethesda; US CT New Haven
- 专利权人: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,YALE UNIVERSITY
- 当前专利权人: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,YALE UNIVERSITY
- 当前专利权人地址: US MD Bethesda; US CT New Haven
- 代理机构: Cantor Colburn LLP
- 国际申请: PCT/US2018/058257 WO 20181030
- 国际公布: WO2019/089626 WO 20190509
- 主分类号: C07D491/113
- IPC分类号: C07D491/113 ; C07D401/14 ; C07D401/12 ; C07D215/54 ; C07D491/107 ; C07D413/04 ; C07D519/00 ; C07D401/04 ; C07D471/04 ; C07D495/04 ; C07D495/10 ; C07D401/06 ; C07D409/14
摘要:
The disclosure provides compounds of Formula I, which may be useful as aldehyde dehydrogenase inhibitors and the pharmaceutically acceptable salts thereof. The variables, J, R4, G, Q, and ring A are defined herein. Aldehyde dehydrogenase inhibitors of Formula I are useful for treating a variety of conditions including cancer and inflammation. The disclosure includes methods for using compounds and salts of Formula I to treat colon cancer, pancreatic cancer, nasopharyngeal carcinoma, thyroid cancer, prostate cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, hepatocellular carcinoma, leukemia, brain tumors breast cancer, atherosclerosis, ischaemic heart disease, acne vulgaris, asthma, autoimmune diseases, autoinflammatory diseases, chronic prostatitis, glomerulonephritis, inflammatory bowel disease, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, vasculitis, and interstitial cystitis. The disclosure also includes pharmaceutical compositions containing a compound or salt of Formula I.
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