公开(公告)号：US20250034620A1

公开(公告)日：2025-01-30

申请号：US18835094

申请日：2023-02-03

Applicant: Yale University

Inventor： Anna Marie Pyle ,  Olga Fedorova ,  Qusay Omran

IPC: C12Q1/6818 ,  C12Q1/6895

Abstract: Described herein is a probe for monitoring specific RNA splicing events, with utility for identifying molecular modulators of RNA splicing. The probe includes a nucleic acid, a first fluorescent element attached to a first end of the nucleic acid, and a second fluorescent element attached to a second end of the nucleic acid. The fluorescence signal of the probe changes when the probe hybridizes with either a pre-splicing RNA molecule or a splicing product. Also described herein is a method of monitoring RNA splicing and a method of screening of modulators of RNA splicing using the probe.

公开(公告)号：US12168639B2

公开(公告)日：2024-12-17

申请号：US18153160

申请日：2023-01-11

Applicant: YALE UNIVERSITY

Inventor： Gerald I. Shulman ,  David A. Spiegel

IPC: C07C205/37 ,  A61K31/085 ,  C07J41/00

Abstract: The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

公开(公告)号：US20240408816A1

公开(公告)日：2024-12-12

申请号：US18653162

申请日：2024-05-02

Applicant: Yale University

Inventor： Michael Mak ,  Xiangyu Gong ,  Zixie Liang

IPC: B29C64/209 ,  B33Y70/10

Abstract: The present invention provides methods for bioprinting collagen and extracellular matrix-based bioinks, and articles such as engineered tissues, comprising the bioinks. In other aspects, the present invention relates to a bioprinting system including a 3D bioprinter with a nozzle, at least one bioink, a support bath solution, wherein the support bath solution comprises PEG (polyethylene glycol) and agarose.

公开(公告)号：US12157903B2

公开(公告)日：2024-12-03

申请号：US17052199

申请日：2019-05-07

Applicant: YALE UNIVERSITY

Inventor： Demetrios Braddock ,  Clemens Bergwitz

IPC: C12N9/14 ,  A61P13/12 ,  A61K38/00

Abstract: The present invention includes compositions and methods for treating and/or preventing renal and/or kidney stones in a human subject. In certain embodiments, the subject is administered certain ENPP1 polypeptides or ENPP3 polypeptides, mutants, or mutant fragments thereof.

公开(公告)号：US20240392478A1

公开(公告)日：2024-11-28

申请号：US18691687

申请日：2022-09-30

Applicant: Yale University

Inventor： Bilige Yang ,  Robert Baines ,  Xiaonan Huang ,  Rebecca Kramer-Bottiglio ,  Dylan Shah

IPC: D01F8/14 ,  A41D19/00 ,  D01D5/42

Abstract: The present invention relates to fiber jamming systems capable of tuning tensile stiffness of soft systems within seconds without the use of high voltage or temperature changes. The systems employ segmented fibrils of interspersed segments of stretchable and non-stretchable materials. Applying a vacuum to the fibrils in an enclosed volume elicits a large interfacial shear resistance to tensile displacement. In the absence of a vacuum, the fibrils are free to stretch and bend in any direction.

公开(公告)号：US20240382599A1

公开(公告)日：2024-11-21

申请号：US18623722

申请日：2024-04-01

Applicant: Arvinas Operations, Inc. ,  Yale University

Inventor： Andrew P. Crew ,  Kurt Zimmermann ,  Jing Wang ,  Michael Berlin ,  Hanqing Dong ,  Alexey Ishchenko ,  Yimin Qian ,  Saul Jaime-Figueroa ,  George Burslem ,  Craig M. Crews

IPC: A61K47/54 ,  A61K31/427 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/55 ,  A61K31/551 ,  A61K38/07 ,  A61K45/06 ,  A61K47/55 ,  C07D471/04

Abstract: The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK1. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBK1 such that TBK1 is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBK1. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBK1.

公开(公告)号：US20240374679A1

公开(公告)日：2024-11-14

申请号：US18669821

申请日：2024-05-21

Applicant: Yale University

Inventor： Aaron Ring

IPC: A61K38/16 ,  A61P35/00 ,  C07K14/54 ,  G06G7/48 ,  G06G7/58

Abstract: The present disclosure provides methods of making and methods of using IL-18 mimic polypeptides for use in therapeutic and non-therapeutic applications. The synthetic IL-18 mimics an increase IL-18R signaling activity even in the presence of an inhibitory molecule such as IL-18BP.

公开(公告)号：US20240343859A1

公开(公告)日：2024-10-17

申请号：US18628340

申请日：2024-04-05

Applicant: University of Rhode Island Board of Trustees ,  Yale University

Inventor： Matthew Kiesewetter ,  Kassie Picard ,  Jinal Pothupitiya ,  W. Mark Saltzman

IPC: C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC classification number: C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

Abstract: Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.

公开(公告)号：US12110278B2

公开(公告)日：2024-10-08

申请号：US17500622

申请日：2021-10-13

Applicant: YALE UNIVERSITY

Inventor： William L. Jorgensen ,  Joseph Schlessinger

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D249/14 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I.

公开(公告)号：US20240325494A1

公开(公告)日：2024-10-03

申请号：US18626930

申请日：2024-04-04

Applicant: YALE UNIVERSITY

Inventor： Aaron Ring ,  Ting Zhou ,  Suzanne Fischer

IPC: A61K38/20 ,  A61K35/17 ,  A61K35/768 ,  A61K38/17 ,  A61K47/64 ,  A61P35/00 ,  C07K14/54 ,  C07K14/705 ,  C12N15/85

CPC classification number: A61K38/20 ,  A61K47/642 ,  A61P35/00 ,  C07K14/54 ,  C12N15/85 ,  A61K35/17 ,  A61K35/768 ,  A61K38/1774 ,  A61K2300/00 ,  C07K14/70596 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50

Abstract: The present invention provides compositions and methods comprising an activator of interleukin-18 (IL-18) activity for use in therapeutic and non-therapeutic applications. The activator provides IL-18 signaling activity even in the presence of an inhibitory molecule 5 such as IL-18 binding protein (IL-18BP).