- 专利标题: Compositions and methods using a single-domain antibody binding transferrin and protein A for increasing protein half-life in serum
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申请号: US16755268申请日: 2017-10-11
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公开(公告)号: US11505601B2公开(公告)日: 2022-11-22
- 发明人: Yafeng Zhang , Shu Wu , Fei Sun , Shuai Yang , Chuan-Chu Chou
- 申请人: NANJING LEGEND BIOTECH CO., LTD.
- 申请人地址: CN Nanjing
- 专利权人: NANJING LEGEND BIOTECH CO., LTD.
- 当前专利权人: NANJING LEGEND BIOTECH CO., LTD.
- 当前专利权人地址: CN Nanjing
- 代理机构: Ice Miller LLP
- 国际申请: PCT/US2017/056125 WO 20171011
- 国际公布: WO2019/074498 WO 20190418
- 主分类号: C07K16/18
- IPC分类号: C07K16/18 ; C07K19/00 ; C07K14/79 ; A61K39/395 ; A61K47/68 ; C12N15/63
摘要:
Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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