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公开(公告)号：US11708410B2
公开(公告)日：2023-07-25
申请号：US15733364
申请日：2019-01-15
发明人： Xinpo Jiang , Shuai Yang , Chuan-Chu Chou
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/39541 , A61K45/06 , A61P35/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes TIGIT. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen-binding fragment thereof.
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公开(公告)号：US20210070855A1
公开(公告)日：2021-03-11
申请号：US16964828
申请日：2019-01-24
发明人： Tao Zhao , Huihui Zhang , Shuai Yang , Yun Zhang , Chuan-Chu Chou , Shu Wu
摘要： Provided are antibodies including monoclonal, human, primate, rodent, mammalian, chimeric, humanized and CDR-grafted antibodies, and antigen binding fragments and antigen binding derivatives thereof. These antibodies bind to CD47 protein, particularly human CD47, modulate, e.g., inhibit, block, antagonize, neutralize or otherwise interfere with CD47 expression, activity and/or signaling, including inhibiting CD47 and SIRPa interaction; do not cause a significant level of hemagglutination of human red blood cells. These antibodies may not enhance RBC phagocytosis.
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公开(公告)号：US11673954B2
公开(公告)日：2023-06-13
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61P35/00 , A61K2039/505 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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公开(公告)号：US11472881B2
公开(公告)日：2022-10-18
申请号：US16341034
申请日：2017-10-10
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Also provided are methods of making and using these constructs.
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公开(公告)号：US20220135687A1
公开(公告)日：2022-05-05
申请号：US15733313
申请日：2018-12-28
发明人： Shuai Yang , Chuan-Chu Chou , Shu Wu , Liusong Yin , Feng Lin
摘要： The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes PD-L1. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen binding fragment thereof.
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公开(公告)号：US11905327B2
公开(公告)日：2024-02-20
申请号：US16958397
申请日：2018-12-28
发明人： Wang Zhang , Shu Wu , Shuai Yang , Qi Pan , Chuan-Chu Chou
IPC分类号： C07K16/02 , A61K39/395 , A61P35/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US11505601B2
公开(公告)日：2022-11-22
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng Zhang , Shu Wu , Fei Sun , Shuai Yang , Chuan-Chu Chou
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US11958903B2
公开(公告)日：2024-04-16
申请号：US17043054
申请日：2019-03-29
发明人： Wang Zhang , Shuai Yang , Shu Wu , Chuan-Chu Chou
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/92
摘要： The present application provides anti-LAG-3 constructs comprising a single-domain antibody (sdAb) that specifically recognizes LAG-3. Also provided are methods of making and using these constructs.
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公开(公告)号：US11713353B2
公开(公告)日：2023-08-01
申请号：US16962023
申请日：2019-01-15
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
CPC分类号： C07K16/2818 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.
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公开(公告)号：US11447573B2
公开(公告)日：2022-09-20
申请号：US16319224
申请日：2017-07-20
发明人： Chuan-Chu Chou , Yafeng Zhang , Shu Wu , Zhenyu Liu , Zhongdao Li , Fangliang Zhang
IPC分类号： C07K16/46 , C07K16/28 , A61P35/00 , A61P37/00 , A61P29/00 , C07K16/24 , C07K16/30 , A61K39/00
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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