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公开(公告)号：US20230338422A1
公开(公告)日：2023-10-26
申请号：US18014627
申请日：2021-07-09
发明人： Qingling Jiang , Yafeng Zhang , Shu Wu , Chunjing Wu
摘要： The present disclosure relates to a novel platform for immunotherapy which combines CAR or TCR engineered γδ T cells with armoring interleukin IL-36 that can be expressed constitutively or inducibly, or with a chimeric cytokine receptor comprising the endodomain of the IL-36 receptor. The system/platform and the associated methods according to the present disclosure have advantages such as increased immune cell potency and persistence for therapeutic applications.
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公开(公告)号：US20230144237A1
公开(公告)日：2023-05-11
申请号：US17605290
申请日：2020-04-22
发明人： Zhongyuan Tu , Hezhong Zhang , Yafeng Zhang , Shu Wu
IPC分类号： C07K14/725 , C12N5/0783 , C12N15/86 , C07K16/30 , C07K16/28 , A61K35/17
CPC分类号： C07K14/7051 , C12N5/0636 , C12N15/86 , C07K16/30 , C07K16/2866 , C07K16/28 , A61K35/17 , C12N2740/15043 , C12N2501/2302 , C07K2319/00
摘要： The present disclosure provides systems for inducing activity of immune cells and methods of immunotherapy. Systems of the present disclosure for inducing immune cell activity comprise a chimeric antigen receptor, a T cell receptor, and various combinations thereof.
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公开(公告)号：US11505601B2
公开(公告)日：2022-11-22
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng Zhang , Shu Wu , Fei Sun , Shuai Yang , Chuan-Chu Chou
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US11713353B2
公开(公告)日：2023-08-01
申请号：US16962023
申请日：2019-01-15
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
CPC分类号： C07K16/2818 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20230226181A1
公开(公告)日：2023-07-20
申请号：US18011766
申请日：2021-06-22
发明人： Zhongyuan Tu , Yafeng Zhang , Shu Wu , Yi Xu
IPC分类号： A61K39/00 , C07K14/725 , C07K14/715 , C07K16/28 , A61P35/00 , C07K14/705 , C07K16/30 , C07K14/54
CPC分类号： A61K39/4611 , C07K14/7051 , C07K14/7155 , C07K16/2803 , C07K16/2878 , A61P35/00 , C07K14/70578 , C07K16/303 , A61K39/464474 , A61K39/464412 , C07K14/70521 , C07K14/54 , A61K39/464417 , A61K39/4631 , A61K2239/28
摘要： The present disclosure relates to a novel platform for immunotherapy which combines CAR engineered γδ T cells with armoring interleukin IL-18 that can be expressed constitutively or inducibly, or with a chimeric cytokine receptor comprising the endodomain of the IL-18 receptor. The system/platform and the associated methods according to the present disclosure have advantages such as increased immune cell potency and persistence for therapeutic applications.
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公开(公告)号：US11447573B2
公开(公告)日：2022-09-20
申请号：US16319224
申请日：2017-07-20
发明人： Chuan-Chu Chou , Yafeng Zhang , Shu Wu , Zhenyu Liu , Zhongdao Li , Fangliang Zhang
IPC分类号： C07K16/46 , C07K16/28 , A61P35/00 , A61P37/00 , A61P29/00 , C07K16/24 , C07K16/30 , A61K39/00
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US11673954B2
公开(公告)日：2023-06-13
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61P35/00 , A61K2039/505 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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公开(公告)号：US11472881B2
公开(公告)日：2022-10-18
申请号：US16341034
申请日：2017-10-10
发明人： Yafeng Zhang , Shu Wu , Shuai Yang , Chuan-Chu Chou
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Also provided are methods of making and using these constructs.
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公开(公告)号：US20220265709A1
公开(公告)日：2022-08-25
申请号：US17251310
申请日：2019-06-19
发明人： Huihui Zhang , Fangliang Zhang , Tao Zhao , Ming Zeng , Yafeng Zhang , Wang Zhang , Shu WU , Qi Pan , Shuai Yang
摘要： A system for inducing activity of immune cells, comprises a chimeric antigen receptor, a T cell receptor, and various combinations thereof.
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