![Process for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one](/docs/US/2022-12-13/US11524957B2/abs.jpg.600x600.jpg)
- 专利标题： Process for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one
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申请号： US17044366申请日： 2019-04-01
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公开(公告)号： US11524957B2公开(公告)日： 2022-12-13
- 发明人: Lei Zhu , John Daniel Bailey , Landon Durak , Joshua David Waetzig , Masahiro Mizuno , Kazuhiro Maeda , Tsuneo Yasuma , Hiroshi Yamaguchi , Koichiro Fukuoka , Kazuyuki Akiyama
- 申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 申请人地址： JP Osaka
- 专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人地址： JP Osaka
- 代理机构： Honigman LLP
- 代理商 Lucy X. Yang; Jonathan P. O'Brien
- 国际申请： PCT/JP2019/015237 WO 20190401
- 国际公布： WO2019/194319 WO 20191010
- 主分类号： C07D453/02
- IPC分类号： C07D453/02 ; C07D409/04
![Process for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one](/abs-image/US/2022/12/13/US11524957B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 {3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.
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