公开(公告)号：US11524957B2

公开(公告)日：2022-12-13

申请号：US17044366

申请日：2019-04-01

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Lei Zhu ,  John Daniel Bailey ,  Landon Durak ,  Joshua David Waetzig ,  Masahiro Mizuno ,  Kazuhiro Maeda ,  Tsuneo Yasuma ,  Hiroshi Yamaguchi ,  Koichiro Fukuoka ,  Kazuyuki Akiyama

IPC分类号： C07D453/02 ,  C07D409/04

摘要： The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 {3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.

公开(公告)号：US11795178B2

公开(公告)日：2023-10-24

申请号：US17694635

申请日：2022-03-14

申请人： Takeda Pharmaceutical Company Limited

发明人： Koichiro Fukuoka ,  Kazuhiro Miwa ,  Tsuyoshi Sasaki ,  Fumiya Komura

IPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

CPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

摘要： The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrirnidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

公开(公告)号：US20150266891A1

公开(公告)日：2015-09-24

申请号：US14432188

申请日：2013-09-27

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Koichiro Fukuoka ,  Kazuhiro Miwa ,  Tsuyoshi Sasaki ,  Fumiya Komura

IPC分类号： C07D495/04 ,  C07D409/12

CPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

摘要： The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethyl aminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

摘要翻译： 本发明提供具有促进促性腺激素释放激素（GnRH）拮抗作用的噻吩并嘧啶衍生物或其盐的高产率的制造方法。 本发明提供一种噻吩并嘧啶衍生物的制备方法，其包括使6-（4-氨基苯基）-1-（2,6-二氟苄基）-5-二甲基氨基甲基-3-（6-甲氧基哒嗪-3-基）噻吩并 [2,3-d]嘧啶-2,4（1H，3H） - 二酮或其盐，1,1'-羰基二咪唑或其盐和甲氧胺或其盐等。

公开(公告)号：US20210101897A1

公开(公告)日：2021-04-08

申请号：US17044366

申请日：2019-04-01

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Lei Zhu ,  John Daniel Bailey ,  Landon Durak ,  Joshua David Waetzig ,  Masahiro Mizuno ,  Kazuhiro Maeda ,  Tsuneo Yasuma ,  Hiroshi Yamaguchi ,  Koichiro Fukuoka ,  Kazuyuki Akiyama

IPC分类号： C07D453/02 ,  C07D409/04

摘要： The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 (3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.

公开(公告)号：US09758528B2

公开(公告)日：2017-09-12

申请号：US14432188

申请日：2013-09-27

申请人： Takeda Pharmaceutical Company Limited

发明人： Koichiro Fukuoka ,  Kazuhiro Miwa ,  Tsuyoshi Sasaki ,  Fumiya Komura

IPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

CPC分类号： C07D495/04 ,  C07D333/38 ,  C07D409/12

摘要： The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethyl aminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.