Invention Grant
- Patent Title: Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
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Application No.: US14436722Application Date: 2013-10-21
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Publication No.: US11535874B2Publication Date: 2022-12-27
- Inventor: Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
- Applicant: Genomatica, Inc.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Greenberg Traurig
- International Application: PCT/US2013/065887 WO 20131021
- International Announcement: WO2014/066235 WO 20140501
- Main IPC: C12N9/96
- IPC: C12N9/96 ; C12P7/46 ; C12N9/04 ; C12N9/06 ; C12N9/10 ; C07C55/10 ; C08G63/00 ; C12N15/70 ; C12N15/81 ; C12P7/24 ; C07C59/235 ; C12N15/74 ; C12N15/77
Abstract:
Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
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