-
公开(公告)号：US12054760B2
公开(公告)日：2024-08-06
申请号：US17755191
申请日：2019-12-17
发明人： Zhen Kang , Jian Chen , Litao Hu , Guocheng Du , Yang Wang , Jianghua Li , Jialian Li , Tianmeng Zhang
CPC分类号： C12P19/04 , C12N1/205 , C12N9/1051 , C12N9/2474 , C12N15/77 , C12Y204/01212 , C12Y302/01035 , C12N2800/101 , C12R2001/15
摘要： The invention discloses a recombinant Corynebacterium glutamicum for efficient synthesis of highly pure hyaluronic acid and oligosaccharides thereof, belonging to the technical field of bioengineering. The recombinant Corynebacterium glutamicum constructed in the present invention can produce hyaluronic acid with a yield up to 40 g/L, and a crude product purity of 95%. Addition of exogenous hyaluronic acid hydrolase and optimization of the fermentation conditions results in hyaluronic acid oligosaccharides with specific molecular weight, and can further improve the yield of hyaluronic acid to 72 g/L. The invention lays a solid foundation for the efficient synthesis of highly pure hyaluronic acid by microorganisms, and the constructed recombinant Corynebacterium glutamicum is suitable for industrial production and application.
-
公开(公告)号：US20240229049A1
公开(公告)日：2024-07-11
申请号：US18560239
申请日：2022-03-03
发明人： Goun PARK , Sojung PARK , Han Hyoung LEE , Woosung CHOI , Heejung KIM , Jaemin LEE
CPC分类号： C12N15/77 , C12N9/0016 , C12P13/06 , C12P13/08 , C12N2800/60 , C12N2830/34 , C12R2001/15 , C12Y104/01003
摘要： The present disclosure relates to relates to promoter variants and Corynebacterium mutant strain, and methods of use thereof.
-
公开(公告)号：US20240150731A1
公开(公告)日：2024-05-09
申请号：US18280575
申请日：2022-03-10
发明人： Jin Sook CHANG , Ju-yeon KIM , Seon Hye KIM , Hyung Joon KIM , Byoung Hoon YOON , Heeseok LEE
CPC分类号： C12N9/1025 , C12N15/77 , C12P13/08 , C12R2001/15 , C12Y203/03001
摘要： The present disclosure relates to a novel citrate synthase variant, a microorganism comprising the variant, and a method for producing L-amino acids using the microorganism.
-
公开(公告)号：US11965200B2
公开(公告)日：2024-04-23
申请号：US17549757
申请日：2021-12-13
发明人： Sang Yup Lee , Tae hee Han
CPC分类号： C12P7/44 , C12N15/77 , C12R2001/15
摘要： The present invention relates to a recombinant microorganism imparted with increased ability to produce glutaric acid by further introducing a gene encoding a polypeptide having glutaric acid transporter activity into a microorganism having ability to produce glutaric acid, and to a method of preparing glutaric acid using the recombinant microorganism. According to the present invention, glutaric acid used for the preparation of various compounds such as polyamide, polyurethane, 1,5-pentanediol, and 5-hydroxyvaleric acid can be biosynthesized at high yield.
-
公开(公告)号：US11919928B2
公开(公告)日：2024-03-05
申请号：US17499599
申请日：2021-10-12
IPC分类号： C07K14/37 , C07K7/64 , C12N9/02 , C12N9/10 , C12N15/70 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/81 , C12P21/02 , C12N1/14
CPC分类号： C07K14/37 , C07K7/64 , C12N9/0077 , C12N9/10 , C12N9/1007 , C12N15/70 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/81 , C12P21/02 , C12N1/14
摘要： An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
-
公开(公告)号：US11898188B2
公开(公告)日：2024-02-13
申请号：US16962213
申请日：2019-01-15
发明人： Sang Yup Lee , Jae Sung Cho , Je Woong Kim , Yoo Sung Ko , Cindy Pricilia Surya Prabowo , Taehee Han , Euiduk Kim , Jae Won Choi , Changhee Cho , Jun Kyu Lee
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/1205 , C12N9/88 , C12N15/77 , C12Y101/01006 , C12Y101/01202 , C12Y207/0103 , C12Y402/0103
摘要： The present disclosure relates to a mutant microorganism in which a glycerol catabolic pathway and a 1,3-PDO biosynthetic pathway are introduced into a microorganism incapable of using glycerol as a carbon source, and a method of producing 1,3-PDO using the same. According to the present disclosure, it is possible to produce 1,3-PDO while growing a mutant microorganism having 1,3-PDO production ability by using the inexpensive raw material glycerol as a single carbon source. Thus, the present disclosure is useful for the economical production of 1,3-PDO.
-
7.发明公开公开(公告)号：US20240018558A1
公开(公告)日：2024-01-18
申请号：US18037320
申请日：2021-11-19
发明人： Su Jin CHOI , Sunyoung YANG , Kwang Woo LEE
CPC分类号： C12P13/14 , C12N9/88 , C12N15/77 , C12Y401/01032 , C12R2001/15
摘要： The present disclosure relates to a microorganism having enhanced L-glutamine production ability and an L-glutamine production method using the same.
-
公开(公告)号：US20230322871A1
公开(公告)日：2023-10-12
申请号：US18338584
申请日：2023-06-21
申请人： Biological E Limited
IPC分类号： C07K14/315 , A61K39/09 , C12N15/77 , A61K47/64 , A61K39/116
CPC分类号： C07K14/3156 , A61K39/092 , C12N15/77 , A61K47/646 , A61K39/116 , A61K2039/6068
摘要： The present invention relates to expression of Pneumococcal Surface Protein A (PspA). The invention represents an advancement in the field of genetic engineering and vaccine technology. The invention discloses expression vectors and recombinant host cells for expression of truncated PspA peptide. The invention also discloses vaccine compositions comprising the truncated peptides as carrier protein.
-
公开(公告)号：US20230192778A1
公开(公告)日：2023-06-22
申请号：US16630203
申请日：2018-07-12
申请人： BIOSYNTIA APS
摘要： The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes encoding polypeptides that enhance the biosynthesis of either biotin, lipoic acid or thiamine. The invention provides a method for producing either biotin, lipoic acid or thiamine using the genetically modified bacterium of the invention; as well as for the use of the genetically modified bacterial cell for either biotin, lipoic acid or thiamine production.
-
公开(公告)号：US11661616B2
公开(公告)日：2023-05-30
申请号：US16638974
申请日：2019-03-27
发明人： Ji Yeon Lee , Jin Sook Chang , Hyung Joon Kim , Byoung Hoon Yoon , Sun Hyoung Choi , Yunjung Choi
CPC分类号： C12P13/04 , C12N1/20 , C12N9/1077 , C12N9/14 , C12N15/77 , C12P13/14 , C12Y204/02017 , C12Y306/01031 , C12N2830/55
摘要： The present disclosure relates to a microorganism having increased glycine productivity and a method for producing a fermented composition using the microorganism, and more specifically, to a microorganism of the genus Corynebacterium having increased glycine productivity due to the introduction of a mutation in HisG, a method for preparing a fermented composition comprising glycine and glutamic acid using the microorganism of the genus Corynebacterium, and the fermented composition.
-
-
-
-
-
-
-
-
-
搜索结果
468 条记录 (耗时 0.027 秒)
