- Patent Title: Recombinant microorganism capable of growing using only carbon dioxide and formic acid and method for producing useful substances using the recombinant microorganism
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Application No.: US17366269Application Date: 2021-07-02
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Publication No.: US11542483B2Publication Date: 2023-01-03
- Inventor: Sang Yup Lee , Junho Bang , Chang Hun Hwang , Jung Ho Ahn , Jong An Lee
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Hultquist, PLLC
- Agent Steven J. Hultquist
- Priority: KR10-2020-0086811 20200714
- Main IPC: C12P7/46
- IPC: C12P7/46 ; C12N9/10 ; C12P7/02 ; C12N9/04 ; C12N9/00 ; C12N9/78 ; C12P7/16 ; C12P7/04 ; C12P13/10 ; C12P5/00 ; C12P5/02 ; C12P13/00 ; C12P7/42 ; C12P17/10 ; C12P13/06 ; C12P13/08

Abstract:
Disclosed is a recombinant microorganism capable of growing using only carbon dioxide and formic acid by introducing and improving a metabolic pathway for synthesizing pyruvic acid from carbon dioxide and formic acid to enhance pyruvic acid synthesis efficiency and performing additional genetic manipulation, and a method for producing useful substances using the same. Advantageously, the recombinant microorganism is capable of synthesizing pyruvic acid, a C3 organic compound, at a remarkably improved rate, and in particular, grows well even in a medium containing only carbon dioxide and formic acid as carbon sources without a glucose supply, and is thereby capable of synthesizing pyruvic acid and various high value-added compounds using the same as an intermediate product in an economically efficient manner.
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