发明授权
- 专利标题： Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
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申请号： US17096150申请日： 2020-11-12
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公开(公告)号： US11548871B2公开(公告)日： 2023-01-10
- 发明人: Brian P. Bestvater , Zhimin Du , Julie Farand , Gregory Notte , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
- 申请人： Gilead Sciences, Inc.
- 申请人地址： US CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Foster City
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D413/04 ; A61K31/65 ; A61P11/00 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14
摘要：
The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).
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