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公开(公告)号：US11584738B2
公开(公告)日：2023-02-21
申请号：US17319507
申请日：2021-05-13
发明人： Brian P. Bestvater , Zhimin Du , Julie Farand , Joshua A. Kaplan , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
IPC分类号： C07D401/14 , C07D409/14 , C07D405/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：US20210024494A1
公开(公告)日：2021-01-28
申请号：US16923750
申请日：2020-07-08
发明人： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D401/14 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , C07D471/08
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20200157094A1
公开(公告)日：2020-05-21
申请号：US16660219
申请日：2019-10-22
发明人： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC分类号： C07D471/04 , C07D513/04 , C07D401/12 , C07D413/10 , C07D217/04 , C07D401/14 , C07D471/08 , C07D487/04 , C07D495/04
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US09655944B2
公开(公告)日：2017-05-23
申请号：US15185273
申请日：2016-06-17
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC分类号： A61K38/21 , A61K38/06 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/08 , C07K5/083 , A61K38/00
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20150175655A1
公开(公告)日：2015-06-25
申请号：US14412331
申请日：2013-07-02
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
摘要： Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US20230212155A1
公开(公告)日：2023-07-06
申请号：US18060934
申请日：2022-12-01
发明人： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00
CPC分类号： C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/2818
摘要： Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US11548871B2
公开(公告)日：2023-01-10
申请号：US17096150
申请日：2020-11-12
发明人： Brian P. Bestvater , Zhimin Du , Julie Farand , Gregory Notte , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
IPC分类号： C07D498/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/04 , A61K31/65 , A61P11/00 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).
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公开(公告)号：US20210380561A1
公开(公告)日：2021-12-09
申请号：US17319471
申请日：2021-05-13
IPC分类号： C07D403/10 , C07D401/10 , C07D413/10 , C07D498/04 , C07D401/14 , C07D413/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non alcoholic steatohepatitis (NASH).
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公开(公告)号：US10316049B2
公开(公告)日：2019-06-11
申请号：US15380836
申请日：2016-12-15
发明人： Zhimin Du , David Dornan , Juan A. Guerrero , Joshua A. Kaplan , John E. Knox , Devan Naduthambi , Barton W. Phillips , Susanna Y. Stinson , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins
IPC分类号： A61K31/505 , A61K45/06 , C07D239/42 , C07D401/10 , C07D413/12 , C07F9/6558 , C07D405/12 , A61K31/4433 , A61K31/519 , A61K9/00 , C07D403/10 , A61K31/4439 , C07D401/12 , A61K31/4545 , C07D401/14 , A61K31/506 , C07D413/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K31/675
摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:
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公开(公告)号：US20160130300A1
公开(公告)日：2016-05-12
申请号：US14996961
申请日：2016-01-15
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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