A slot resource configuration method in wireless communication and a device are provided, to resolve a problem of how to configure a flexible resource included in a new slot structure. In this method, user equipment-specific downlink control information (UE-specific DCI) sent by a base station is received, where the UE-specific DCI indicates a use configuration status of a flexible resource in at least one slot; and the flexible resource is configured according to the use configuration status. This method implements configuration of a flexible resource, so that the flexible resource can be used for communication, thereby improving slot resource usage.