Methods and systems described perform air cleaning and/or sanitization in a heating, ventilation, air conditioning, and/or refrigeration (HVACR) system by detecting a concentration of airborne contaminants in a space serviced by the HVACR system. The detected concentration of airborne contaminants is determined whether it exceeds a threshold relative to a capacity of a first air cleaner. When the detected concentration of airborne contaminants exceeds the threshold, a second air cleaner is selected and enabled to be activated in the space. When the detected concentration of airborne contaminants does not exceed the threshold, the first air cleaner is selected and enabled to be activated in the space. The first air cleaner has a cleaning material different from the second air cleaner, and the first air cleaner, relative to the second air cleaner, treats the space at a lower concentration of airborne contaminants. The second air cleaner includes specifically designed cleaner modules.